HSD17B6 Antikörper (N-Term)

Produktnummer ABIN2776865

Dieser Anti-HSD17B6 Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von HSD17B6 in WB und IHC. Geeignet für Human, Maus, Ratte, Hund, Rind (Kuh), Pferd, Meerschweinchen und Kaninchen. Dieses Primary Antibody wurde in 2+ Publikationen zitiert.

Kurzübersicht für HSD17B6 Antikörper (N-Term) (ABIN2776865)

Target: HSD17B6 (Hydroxysteroid (17-Beta) Dehydrogenase 6 (HSD17B6))

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Pferd, Meerschweinchen, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HSD17B6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-HSD17B6 Antikörper

Bindungsspezifität: N-Term

Sequenz: MWLYLAAFVG LYYLLHWYRE RQVVSHLQDK YVFITGCDSG FGNLLARQLD

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 100%, Rabbit: 79%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against HSD17B6. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HSD17B6

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 317 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-HSD17B6 Antikörper (ABIN2776865)

Mohler, Titus, Bai, Kennerley, Lih, Tomer, Wilson: "Activation of the androgen receptor by intratumoral bioconversion of androstanediol to dihydrotestosterone in prostate cancer." in: Cancer research, Vol. 71, Issue 4, pp. 1486-96, (2011) (PubMed).

Muthusamy, Andersson, Kim, Butler, Waage, Bergerheim, Gustafsson: "Estrogen receptor ? and 17?-hydroxysteroid dehydrogenase type 6, a growth regulatory pathway that is lost in prostate cancer." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 50, pp. 20090-4, (2011) (PubMed).

Details zu HSD17B6

Target: HSD17B6 (Hydroxysteroid (17-Beta) Dehydrogenase 6 (HSD17B6))

Andere Bezeichnung: HSD17B6

Hintergrund: HSD17B6 has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. HSD17B6 is a member of the retinol dehydrogenase family.The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family. Transcript variants utilizing alternative polyadenylation signals exist.
Alias Symbols: HSE, RODH, SDR9C6
Protein Size: 317

Molekulargewicht: 35 kDa

Gen-ID: 8630

NCBI Accession: NM_003725, NP_003716

UniProt: O14756

Pathways: Steroid Hormone Biosynthesis